Rhodiola Rosea for Depression
Verdict: Published with Warning
Across 3 PubMed studies, the evidence for Rhodiola Rosea in Depression grades Tier C — weak evidence. Effective, but with safety or population caveats.
C 🟠 C Weak Evidence Published with Warning
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.56
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
C · Published with Warning
Confidence
67%
Broadly consistent
Evidence level
E3
Single high-quality meta-analysis
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.561
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 無高階證據可裁決
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 1 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (3)L2 · primary research & systematic reviews
Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled t
Finding: All three arms showed modest, statistically non-significant reductions with no between-group differences (HAM-D p=0.79; BDI p=0.28; CGI/C p=0.17); R. rosea trended weaker antidepressant effect than sertraline but had significantly fewer adverse events (30.0% vs 63.2%, placebo 16.7%, p=0.012).
View on PubMed Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression
Finding: Both active doses significantly improved overall depression, insomnia, emotional instability and somatization vs placebo; self-esteem change not significant; exact p-values not reported in abstract.
View on PubMed Rhodiola rosea L. as a putative botanical antidepressant
Finding: Concludes a possible antidepressant action for R. rosea extract with favorable safety vs conventional antidepressants; no quantitative pooled estimate provided.
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Cautious
Rhodiola rosea source↗
L4c UK NHS
Neutral
Rhodiola rosea L. is a plant that grows at high altitudes in the arctic areas of Europe, Asia and North America. It is a traditional herbal medicinal product registered in the UK for the treatment of mental and physical symptoms of stress and overwork, such as fatigue, exhaustion and mild anxiety. source↗
L4d TW TFDA / 衛福部
Neutral
紅景天列於食藥署「可供食品使用原料彙整一覽表」，學名包含 Rhodiola sacra、Rhodiola crenulata、Rhodiola rosea L.、Rhodiola sachalinensis，可供食品使用部位為根。臺灣中藥典亦收載紅景天（景天科大花紅景天之乾燥根及根莖），效能為益氣活血、通脈平喘，分類為補益藥（補氣）。 source↗
L5c Cleveland Clinic
Cautious
Rhodiola alleviates symptoms of fatigue, anxiety and depression. source↗