Nicotinamide Mononucleotide (NMN) for Cardiovascular Disease
NMN has not been shown to prevent or treat cardiovascular disease. The few small human trials report only minor changes in surrogate markers like blood pressure and arterial stiffness, with no evidence on heart attacks, stroke, or survival.
Why this grade7-layer evidence engine
The grade is held to Weak because every human result rests on surrogate endpoints rather than real cardiovascular events. A 2026 meta-analysis of 10 RCTs (PMID 41901064, n=349) found diastolic blood pressure fell by just 2.15 mmHg (p=0.006), while the systolic drop of 1.58 mmHg was not statistically significant; a larger systolic effect appeared only in the over-60 subgroup. An effect this small is of uncertain clinical importance.
The only arterial-stiffness trial (PMID 36797393, n=36, 12 weeks) missed its primary outcome: pulse-wave velocity showed no significant difference versus placebo overall, reaching significance only in a high-BMI, high-glucose subgroup. That study was funded by a supplement company (DHC Corporation), which is why the engine flags industry-funding bias. No trial has measured heart attacks, stroke, or mortality, and most supporting data are animal or mechanistic.
Regulators and major clinics offer no endorsement for this use. The US FDA states NMN 'is excluded from the definition of a dietary supplement,' and EFSA's opinion is purely about safety, deeming up to 300 mg/day safe for the general population, not effective for the heart. NIH ODS, Mayo Clinic, Cleveland Clinic, and Harvard Health have issued no cardiovascular position, reflecting that mainstream medicine does not yet recognize NMN for cardiovascular disease.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.508
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (1 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 1 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status