Coenzyme Q10 for Cardiovascular Disease
For cardiovascular disease broadly, coenzyme Q10 is not proven to help, and major regulators authorize no heart-health claim. The only credible signal is a possible mortality benefit in patients with chronic heart failure (HFrEF) already on standard medication, where it may serve as an adjunct, never a substitute, for guideline therapy.
Why this grade7-layer evidence engine
The strongest data sit in a narrow group: chronic heart-failure (HFrEF) patients on standard therapy. The Q-SYMBIO European subgroup (PMID 30835327, n=231, 300 mg/day) reported lower major cardiovascular events (HR 0.23, 95% CI 0.08-0.64), and a pooled meta-analysis found reduced all-cause mortality (PMID 28738783, RR 0.69, 95% CI 0.50-0.95). But this signal is industry-tied and not robust: the Cochrane review (PMID 35608922) rated mortality as RR 0.58 (95% CI 0.33-1.02) with low-to-moderate quality evidence.
Outside heart failure the case weakens further. No verified meta-analysis of CoQ10 in post-MI or coronary disease showed significant hard-outcome benefit (the previously cited post-MI MA, PMID 35155860, resolved to an unrelated hyperoxaluria transplant paper and has been removed). A blood-pressure meta-analysis (PMID 36130103) found only a small surrogate effect (systolic roughly -3.5 to -4 mmHg) that does not equate to fewer heart attacks or strokes.
Authorities decline to endorse it. EFSA found no established cause-and-effect for any CoQ10 health claim, the US FDA treats disease claims as unapproved 'new drug' marketing, and Harvard Health states there is no convincing evidence it boosts heart health. Mayo and Cleveland Clinic allow only cautious adjunct use in heart failure. Hence Tier C: real but weak and group-specific, not a primary-prevention therapy.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.468
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (4 篇 verified > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status