Coenzyme Q10 for Cardiovascular Disease
For cardiovascular disease broadly, coenzyme Q10 is not proven to help, and major regulators authorize no heart-health claim. The only credible signal is a possible mortality benefit in patients with chronic heart failure (HFrEF) already on standard medication, where it may serve as an adjunct, never a substitute, for guideline therapy.
Why this grade7-layer evidence engine
The strongest data sit in a narrow group: chronic heart-failure (HFrEF) patients on standard therapy. The Q-SYMBIO European subgroup (PMID 33708164, n=231, 300 mg/day) reported lower major cardiovascular events (HR 0.47), and a pooled meta-analysis found reduced all-cause mortality (PMID 34185874, RR 0.69). But this signal is industry-tied and not robust: the Cochrane review (PMID 33513566) rated the same mortality estimate as uncertain (RR 0.68, CI 0.45-1.03, p=0.07) with low-to-moderate quality evidence.
Outside heart failure the case weakens further. A post-MI/coronary meta-analysis showed no significant reduction in recurrent ischemic events (PMID 35155860, HR 0.82, p=0.18), and the blood-pressure benefit is a small surrogate effect (PMID 34746965, systolic -3.65 mmHg) that does not equate to fewer heart attacks or strokes.
Authorities decline to endorse it. EFSA found no established cause-and-effect for any CoQ10 health claim, the US FDA treats disease claims as unapproved 'new drug' marketing, and Harvard Health states there is no convincing evidence it boosts heart health. Mayo and Cleveland Clinic allow only cautious adjunct use in heart failure. Hence Tier C: real but weak and group-specific, not a primary-prevention therapy.
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.468
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (4 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status