Lactobacillus paracasei (K71 / LP33) for Atopic Dermatitis
Verdict: Published with Warning
Across 5 PubMed studies, the evidence for Lactobacillus paracasei (K71 / LP33) in Atopic Dermatitis grades Tier B — preliminary evidence. Effective, but with safety or population caveats.
B 🟡 B Preliminary Evidence Published with Warning
Why this grade7-layer evidence engine
⚖️
Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditableRaw score 0.58
D
C
B
A
S
← counter-evidence / ineffectiveeffective / strong evidence →
Final grade
B · Published with Warning
Confidence
76%
Broadly consistent
Evidence level
E2
Multiple high-quality MAs (≥2 independent, consistent)
▸View the full decision path (audit trail)
- compute_raw_score — 加權公式: L2×0.30 + L3×0.25 + L5×0.25 + L11×0.10 + L1×0.10 = 0.583
- tier_from_score — 依分數區間映射至 tier letter
- apply_hec_rules — 高品質 SR/MA 顯示 positive (3 篇 > 0 negative)
- tier_strict_requirement_check — Tier 條件達標，未降階
- detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
- decide_status — 依 tier + dispute 結果決定 status
PubMed studies (5)L2 · primary research & systematic reviews
Beneficial effect of a diet containing heat-killed Lactobacillus paracasei K71 on adult type atopic dermatitis
Finding: Skin severity score fell significantly from baseline in the heat-killed K71 group at week 8 (P<0.05) and week 12 (P<0.01) but not in placebo, while itch and quality-of-life scores did not differ significantly between groups.
View on PubMed Comparative effectiveness of probiotic strains on the prevention of pediatric atopic dermatitis: A systematic review and network meta-analysis
Finding: L. paracasei ssp paracasei F19 ranked second by SUCRA, but versus placebo RR was 0.49 (95% CI 0.20-1.19, crossing 1, not significant) on very-low-certainty GRADE evidence, so any preventive benefit is uncertain.
View on PubMed Single-Strain Probiotic Lactobacilli for the Treatment of Atopic Dermatitis in Children: A Systematic Review and Meta-Analysis
Finding: The L. paracasei subgroup was not statistically significant (MD -7.39, 95% CI -19.08 to 4.29, p=0.21, I2=96%), whereas overall single-strain lactobacilli reduced SCORAD (MD -4.50, p=0.003) with L. fermentum most and L. rhamnosus least effective.
View on PubMed Meta-analysis on preventive and therapeutic effects of probiotic supplementation in infant atopic dermatitis
Finding: Probiotics lowered AD incidence by about 22% overall (up to 49% with maternal pregnancy-plus-lactation dosing) and L. paracasei (with L. sakei) showed a significant SCORAD decrease in treatment, though benefit was less conclusive for treating infants under 1 year.
View on PubMed Next-Gen biotherapeutics: A systematic review and network meta-analysis on postbiotics as treatment for pediatric atopic dermatitis
Finding: Heat-killed L. paracasei GM080 (LP2) may not reduce AD symptoms versus placebo (SMD -0.03, 95% CI -0.37 to 0.32, low certainty), whereas only heat-killed L. rhamnosus IDCC 3201 achieved a significant SCORAD reduction (MD -5.52, 95% CI -10.46 to -0.58).
View on PubMed Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L5a NIH Office of Dietary Supplements
Cautious
A review of 23 studies (1,919 participants) in which probiotics were tested for treating allergic rhinitis found some evidence that they may be helpful for improving symptoms and quality of life... because the studies tested different probiotics and measured different effects, no recommendations about the use of probiotics could be made. source↗
L5e Specialty Society (condition-mapped)
Against
insufficient evidence or no benefit to dietary or environmental interventions, including early food introduction, human milk consumption, probiotic or vitamin D supplementation, water softening, and dust mite avoidance source↗