Legacy AI grade · Sources dated 2026-06-01. Not expert reviewed. Coverage is limited to the listed sources. About the new summary workflow
MolybdenumforAsthma
Verdict: Unproven: not a verified asthma treatment
There is no reliable evidence that molybdenum supplements treat or prevent asthma. The only basis is an unproven mechanistic hypothesis about sulfite-sensitive asthma, with no modern controlled trials.
U⚫ U Unverified Insufficient Evidence
🔬Why this grade7-layer evidence engine
The engine grades this Unverified (Tier U, Insufficient Evidence). The single piece of human data, a 1990 cross-sectional study of 18 people (no valid human cross-sectional cite remains; PMID 2643005 removed (wrong paper: Exercise and obesity 1989). The removed study only linked low sulfite oxidase activity to sulfite sensitivity; it tested no molybdenum supplement and was rated low quality. All evidence is pre-1995, very small, and uncontrolled, with no modern trial to replicate it.
Regulators treat molybdenum purely as an essential trace mineral, not an asthma therapy. The US FDA sets only a 45 mcg Daily Value, the EU EFSA approves just one claim (it 'contributes to normal sulphur amino acid metabolism'), the UK NHS says a normal diet supplies all you need, and the WHO defines safe intake ranges without any asthma indication.
No major clinic or asthma authority endorses it. The NIH Office of Dietary Supplements states plainly that 'Molybdenum is not a standard treatment for any disease or disorder,' while Mayo Clinic, Cleveland Clinic, Harvard, and the GINA/ATS asthma guidelines do not address it at all. The sulfite-oxidase rationale is a fringe hypothesis limited to a narrow subgroup and remains clinically unproven.
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Scoring transparency
All scores computed by a 7-layer evidence engine — fully auditable
tier_strict_requirement_check — D 級條件未達 (需 E1-E3 negative；實際 E10)
detect_disputes — 偵測到 0 個 hard + 0 個 soft dispute
decide_status — 依 tier + dispute 結果決定 status
🏛️Regulatory & authoritative positionsL4/L5 · FDA / EMA / NIH ODS / Cochrane / Mayo …
L4a US FDA
Supportive
The DV for molybdenum is 45 mcg for adults and children age 4 years and older. source↗
L4b EU EFSA
Supportive
Molybdenum contributes to normal sulphur amino acid metabolism. source↗
L4c UK NHS
Cautious
Molybdenum is found in many different types of food, such as nuts, canned vegetables, peas, leafy vegetables (like broccoli and spinach), cauliflower and cereals. You should be able to get all the molybdenum you need from your daily diet. source↗
Molybdenum is considered to be an essential trace element in both animals and humans. Safe and adequate intake levels have been suggested... namely 0.015-0.04 mg/day for infants, 0.025-0.15 mg/day for children aged 1-10 and 0.075-0.25 mg/day for all individuals above the age of 10. The guideline value of 0.07 mg/litre is consistent with the essential daily requirement for molybdenum. source↗
L5a NIH Office of Dietary Supplements
Supportive
Molybdenum deficiency has not been reported, except in people with a genetic mutation that prevents the synthesis of molybdopterin and therefore of sulfite oxidase. In this rare metabolic disorder, known as molybdenum cofactor deficiency, mutations in one of several genes prevent the biosynthesis of molybdopterin. … Molybdenum is not a standard treatment for any disease or disorder. source↗
✓PMID 100% verifiedevery citation checked via NCBI Entrez
🔬7-layer evidence engineindependently re-checked by multiple sub-agents